Tjitjik Srie Tjahjandarie, Ahmad Rudi Setiawan, Audrey Haznia Zulfa, Ratih Dewi Saputri, Norizan Ahmat, Mulyadi Tanjung
Chalcone derivatives are one of the main flavonoid groups in the genus Flemingia. Generally, Flemingia chalcones have unusual oxygenation patterns, prenyl, and geranyl chains and exhibit cytotoxic and antioxidant activities. The research aims to isolate geranylated chalcone from Flemingia macrophylla leaves and evaluate the cytotoxic and radical scavenging activities. Extraction of geranylated chalcones from F. macrophylla leaves using maceration with methanol. Separation and purification process using gravity column and planar radial chromatography resulted in deoxyhomofleminigin and 3-hydroxyflemingin A. HR-ESI-MS, UV, 1D, and 2D NMR determined the structure of geranylated chalcones. 3-Hydroxyflemingin A shows high activity toward Hela and T47D cells (IC50 values 1.98 and 0.20 µg/mL, respectively). The antioxidant effects of deoxyhomofleminigin and 3- hydroxyflemingin A against DPPH radicals also demonstrated strong activity. © 2025 by SPC (Sami Publishing Company).
Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia; Department of Chemistry, Faculty of Mathematics and Science, Universitas Negeri, Surabaya, Indonesia; Faculty of Applied Sciences, Universiti Teknologi MARA, Selangor, Shah Alam, 40450, Malaysia
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