Sari Edi Cahyaningrum, Nuniek Herdyastuti, Amanah Firdausa, Asri Rahmi
This study was aimed to develop chitosan-calcium alginate-tween 80 nanoparticles as drug carrier to reduce the dosing frequency of isoniazid, an anti tuberculosis drug. In this work calcium alginate was blended with different composition of isoniazid- chitosan- tween 80. The nanoparticles were characterized to determine the particles size, functional groups, surface morphology, particle porosity, % drug entrapment efficiency and in vitro drug controller release. The results showed that the nanoparticles slightly rough surface with good appearance. The drug entrapment efficiency was about 70.56 to 90.61%. Dissolution release isoniazid in pH 1.2 and pH 7.4 indicate more than 90% isoniazid is release from matrix and in pH 1.2 about 30%. © 2015 Sari Edi Cahyaningrum et al.
Department of Chemistry, Faculty of Mathematics and Natural Science, State University of Surabaya, Surabaya, 60231, Indonesia
