Munasir, Nuhaa Faaizatunnisa, Lydia Rohmawati, Muhammad Naufal Ariesta, Suyatno
Curcumin (CUR), a natural water-soluble polyphenol, is widely recognized for its chemo preventive and chemotherapeutic properties. To develop a system with enhanced CUR loading and controlled release capabilities, microporous zeolite Na was synthesized by incorporating magnetic nanoparticle cores (Fe/Si@Zeolite Na). Various characterization techniques—including Fourier Transform Infrared (FTIR) spectroscopy, X-ray powder diffraction (XRD), scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDX), high-resolution transmission electron microscopy (HR-TEM), and Brunauer-Emmett-Teller (BET) analysis—validated the successful synthesis of magnetic Fe/Si@Zeolite Na. Furthermore, FTIR and XRD analyses conducted post-encapsulation confirmed both the successful loading of CUR and the formation of CUR@Fe/Si@Zeolite Na (ZFS). MNPs were employed as a core-shell structure to enhance the biocompatibility of the system and facilitate the controlled release of CUR from the matrix carrier (CUR@Fe/Si@Zeolite Na). The prepared microspheres exhibited rapid release behavior from Zeolite Na without MNPs, demonstrating pH-dependent CUR release rates of 12.09 % at pH 7.4 and 16.72 % at pH 5.8. However, with the incorporation of MNPs, the CUR release rate decreased, with slow-release results for ZFS-21 % indicating 3.05 % at pH 7.4 and 7.89 % at pH 5.8. The DFT results showed that at pH 7.4, curcumin has a lower band gap, leading to stronger interactions with the matrix, which could prolong the release compared to pH 5.8. This controlled slow-release mechanism positions CUR@Fe/Si@Zeolite Na (ZFS) as a promising candidate for use as a biocompatible carrier with regulated drug release capabilities. © 2025
Department of Physics, Faculty of Mathematics and Natural Science, Universitas Negeri Surabaya (UNESA), Kampus Unesa 1, Jl. Ketintang Surabaya, 60231, Indonesia; Department of Chemistry, Faculty of Science and Data Analytics, Institut Teknologi Sepuluh Nopember (ITS), Jl. Arif Rahman Hakim, Kampus ITS Keputih-Sukolilo, Surabaya, 60111, Indonesia; Department of Product and Application Development, LyondellBasell Advanced Polyolefins, Jl. Raya Gempol - Malang No.KM. 39, Pasuruan, 67155, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya (UNESA), Kampus Unesa 1, Jl. Ketintang Surabaya, 60231, Indonesia
