Titik Taufikurohmah, Agoes Soegianto, I Gusti Made Sanjaya, Afaf Baktir, Achmad Syahrani
The effects of heavy metals mercury on the cell proliferation and collagen synthesis from Musmuscullus tissue had the results. This research used laboratory animals Musmucullus as objects of the research. The skin of test animals would exposure to mercury. Mercury material will be included in a pharmaceutical skin cream and placebo treated to control group of test animals. From the description of the dangers of mercury that can cause the tissue damaged. The texture of cross sectional slices the skin of the test animals were exposed to mercury than control is different. The skin animals with mercury exposed has a number of muscle tissue less than control, epidermis and dermis are thinner and fragile than control. While the fat tissue of mercury exposed group had a thicker than the control. The skin animals exposed to mercury had a number of skin fibroblast cells which is smaller than the control at each area. Similarly, percent area collagen of test animals exposed to mercury which is smaller than the control.
Chemistry Department, The State University of Surabaya, Surabaya East Java, Indonesia; Biology Department, Airlangga University, Surabaya East Java, Indonesia; Chemistry Department, Airlangga University, Surabaya East Java, Indonesia; Pharmacy Department, Airlangga University, Surabaya East Java, Indonesia
