Mulyadi Tanjung, Fida Rachmadiarti, Ratih Dewi Saputri, Tjitjik Srie Tjahjandarie
A new isoprenylated 4-phenylcoumarin derivative, mesucalophylloidin (1) along with three known compounds, mammea A/BA cyclo F (2), calolongic acid (3) and isocalolongic acid (4) were isolated from the stem bark of Mesua calophylloides (Ridl.) Kosterm. Structures of all the compounds were elucidated using extensive spectroscopic methods, including UV, IR, HRESIMS, 1D and 2D NMR. Compounds 1–4 were evaluated for their cytotoxicity against P-388 cells, showing that compound 1 gave moderate activity with IC50 6.26 μg/mL. © 2017 Informa UK Limited, trading as Taylor & Francis Group.
Natural Products Chemistry Research Group, Organic Chemistry Division, Faculty of Science and Technology, Department of Chemistry, Universitas Airlangga, Surabaya, Indonesia; Faculty of Mathematics and Natural Sciences, Department of Biology, Universitas Negeri Surabaya, Surabaya, Indonesia
