Ratih Dewi Saputri, Mulyadi Tanjung, Tjitjik Srie Tjahjandarie
A new acridone alkaloid, melixyloidin (1), and two known alkaloids (2-3) were isolated from Melicope xanthoxyloides (F. Muell) T.G. Hartley leaves. The structure of melixyloidin were elucidated using NMR spectra and high-resolution ESIMS data. Acridone alkaloids 1-3 were evaluated against MCF-7 and HeLa cells. 1,3,4-Trimethoxy-10-methylacridin-9-one (2) showed potent cytotoxic activity against MCF-7 cells with an IC50 value of 5.31 μM. © 2021, Korean Society of Pharmacognosy. All rights reserved.
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya, 60231, Indonesia; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia
