Baskoro Nugroho Putro, Junian Cahyanto Wibawa, Vega Mareta Sceisarriya, Novadri Ayubi, Mohd Azzuan Ahmad
Purpose. Sedentary women are at increased risk of metabolic disorders, including changes in purine metabolism. Physical exercise is a non-pharmacological intervention that may help prevent or manage gout. However, the effect of physical exercise on uric acid levels remains unknown. Whether this is a physiological or pathological response requires further research. This study aimed to determine the effect of resistance training and aerobic exercise on uric acid levels in women with a sedentary lifestyle. Materials & Methods. This experimental study used a pretest–posttest control group design. Participants were selected through random sampling, and after they were selected, three groups were formed: the treatment group (RE) received a resistance exercise intervention, an aerobic exercise intervention was given to the treatment group (AE), while the control group (CO) did not do any activity, just sitting. This study involved thirty-nine healthy women with a sedentary lifestyle. Women aged 18 to 26 years participated in this study. Data collection took place over the course of two days, beginning with the collection of information regarding the characteristics of the subjects. Then, before the exercise, the subjects had their blood drawn as pre-test data. The participants were told to warm up. Then, the subjects performed physical exercises according to their group. The exercises performed included resistance and aerobic exercises. After the exercise intervention, blood samples were taken as post-test data. Results. The results showed that resistance exercise significantly increased uric acid levels (CI 95%; p=0.001*; effect size: 2.01) p<0.05 compared with the control group and aerobic exercise did not significantly increase uric acid levels (CI 95%; p=1.000) p>0.05 compared to the control group. However, the resistance exercise had significantly higher uric acid levels than the aerobic exercise group (CI 95%; p=0.000*; effect size: 1.56) p<0.05. Conclusions. Therefore, these experimental test data indicate that acute resistance training increased uric acid levels. However, this is a physiological response. During resistance training, ATP production increases from muscle contraction, resulting in oxidative stress and changes in muscle blood flow (ischemia-reperfusion). This activates xanthine oxidase, which accelerates the conversion of hypoxanthine to uric acid. © 2026 The Author(s).
Department of Physical Education Health and Recreation, Faculty of Sport, Universitas Sebelas Maret, Indonesia; Department of Physical Education Health and Recreation, STKIP PGRI Trenggalek, Indonesia; Department of Physical Education Health and Recreation, Faculty of Sports and Health Sciences, Universitas Negeri Surabaya, Indonesia; Physiotherapy Programme, Centre for Rehabilitation and Special Needs Studies, Faculty of Health Sciences, Universiti Kebangsaan Malaysia, Kuala Lumpur, Malaysia
