Mulyadi Tanjung, Tjitjik Srie Tjahjandarie, Muhammad Fajar Aldin, Shola Mardhiyyah, Norizan Ahmat, Ratih Dewi Saputri
A new flavonol, macagigantin A (1), and three known flavonols (2–4) were isolated from Macaranga gigantea leaves. The structure of macagigantin A was fully assigned by 1D and 2D NMR, UV, and highresolution mass spectra data. The cytotoxic activity of 1–4 was evaluated against 4T1, P-388, and HeLa cells. Compound 1 showed potent activity against 4T1 cells with an IC50 value of 1.18 μg/mL, and compound 3 showed moderate activity against P-388 cells (IC50 value of 2.54 μg/mL). © 2023, Korean Society of Pharmacognosy. All rights reserved.
Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, 60115, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya, 60231, Indonesia; Faculty of Applied Sciences, Universiti Teknologi MARA, Selangor, Shah Alam, 40450, Malaysia
