Alifia Muharram, Diah Ayu Rachmawati, Shola Mardhiyyah, Tjitjik Srie Tjahjandarie, Ratih Dewi Saputri, Norizan Ahmat, Mulyadi Tanjung
Two flavonols, macagigantin (1) and brussoflavonol E (2), and two diterpenoids, deheiculatin C (3) and poilaneic acid (4), were obtained from Macaranga involucrata (Roxb.) Baill. leaves. Their structures were fully detailed on high-resolution electrospray mass spectra, 1D NMR (1H, 13C), and 2D NMR (heteronuclear multiple quantum coherence, heteronuclear multiple bond coherence) spectra. The cytotoxic and antioxidant activities of compounds 1–4 were evaluated in murine leukemia cancer cells (P-388) and DPPH radical assays, respectively. Compounds 1–3 showed moderate activity against P-388 cells with IC50 values of 26.3, 12.8, and 21.2 μM, respectively. Compounds 1–2 showed high activity against DPPH radical with IC50 values of 332.1 and 125.6 μM, respectively. © 2023 Alifia Muharram et al.
Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia; Organic Chemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya, Indonesia; Faculty of Applied Sciences, Universiti Teknologi MARA, Shah Alam, Malaysia
