Isolation of Lignans from The Stem Bark of Willughbeia coriacea and Their Cytotoxic Activity

Andre Harsono; Abror Rahman; Rizqidhana J. Putri; Tjitjik S. Tjahjandarie; Ratih D. Saputri; Norizan Ahmat; Mulyadi Tanjung

doi:10.26538/tjnpr/v7i2.14

Isolation of Lignans from The Stem Bark of Willughbeia coriacea and Their Cytotoxic Activity

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Andre Harsono, Abror Rahman, Rizqidhana J. Putri, Tjitjik S. Tjahjandarie, Ratih D. Saputri, Norizan Ahmat, Mulyadi Tanjung

2023 Tropical Journal of Natural Product Research Vol. 7 Issue 2 Article Cited by 6 SDG 3SDG 17

Abstract

Willughbeia coricea Wall is a herbal medicine to treat diarrhea in Dayak People, Kalimantan, Indonesia. This study aims to determine the structure of the lignans and their anticancer activity against cervical cancer cells (HeLa). Two lignan derivatives, (+)-pinoresinol (1) and alyterinate A (2), were isolated from the roots of the W. coricea Wall. The structures of 1 and 2 were determined based on UV, IR, HRESIMS, 1D (1H and13C), and 2D NMR (HMQC and HMBC) spectroscopic analysis. Compounds 1-2 showed moderate activity against HeLa cells with an IC50 value of 10.1 and 12.5 μM, respectively. © 2023 Harsono et al.

Affiliations

Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, 60115, Indonesia; Organic Chemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya, 60231, Indonesia; Faculty of Applied Sciences, Universiti Teknologi MARA, Selangor, Shah Alam, 40450, Malaysia

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