Novadri Ayubi, Nining Widyah Kusnanik, Lilik Herawati, Cyuzuzo Callixte, Jiang Wen Ming, Mohammed Aljunaid, Deby Tri Mario, Anton Komaini, Dyah Fitria Padmasari
The study aimed to analyze the effect of curcumin on serum NF-kB levels after high-intensity exercise. This experimental research uses a pre and post-control group design. Research subjects were selected using a purposive sampling technique. Following this, the subjects were divided into two groups: Group K1 with a placebo and Group K2 with a dose of 400 mg of curcumin. A total of 20 healthy men aged between 20-30 years participated in this study. On the first day, Data on the characteristics of the research subjects were collected. The subjects warmed up and did high-intensity training in squad exercises and leg presses with an intensity of 80-90% of maximum ability. The intensity of each research subject was determined using the one repetition maximum (1RM) test. 1RM is the maximum weight that can be lifted in one repetition of a movement. The exercise is performed in four sets of 10 repetitions with a recovery time of approximately 60 seconds between set. On the second day, 24 hours after high-intensity exercise, all subjects took blood samples (pre-test) and then were given intervention based on their respective groups. On the third day, 48 hours after high-intensity exercise, all subjects took blood samples (post-test). Blood samples were analyzed in the laboratory using the ELISA method with catalog numbers Human NF-kB ELISA kit E0690Hu. The results of this study reported that the group given curcumin after high-intensity exercise reduced serum NF-kB levels significantly (*p<0.05) compared to the placebo group. It can be concluded that the administration of curcumin at 400 mg after high-intensity exercise can reduce serum NF-kB levels. Reducing NF-kB levels is believed to lessen pro-inflammatory cytokines such as TNF-a and is closely related to muscle pain after exercise. We recommend using curcumin as a natural ingredient that can potentially reduce NF-kB. In future research, we strongly recommend examining other inflammatory biomarkers, such as TNF-a and Interleukin. © Copyright: Federación Española de Asociaciones de Docentes de Educación Física.
Universitas Negeri Surabaya, Indonesia; Universitas Airlangga, Indonesia; University of Rwanda, Rwanda; Sultan Idris Education University, Malaysia; Taiz University, Yemen; Universitas Negeri Padang, Indonesia
