Endik Deni Nugroho, Reza Ardiansyah, Nia Kurniawan, Widodo, Dwi Anggorowati Rahayu, Ahmad Misbakhus Sururi
Macrophiothrix longipeda, also known as the long-legged starfish, is an echinoderm species that exhibits important study potential, particularly within the medical field. Therefore, the present study endeavors to elucidate the chemical composition of M. longipeda and investigate its potential as a source of antiviral agents capable of inhibiting the Covid-19 3CLpro and RdRp enzymes derived from the human SARS-CoV-2 virus, as well as the ACE2 virus. Samples were obtained from Gili Ketapang, Indonesia, by the quadratic transect method. The samples were dried, mashed, and macerated using methanol. Identification of compound content was carried out using GC-MS, and the antiviral potential of compounds was analyzed using in silico molecular docking and the ADME approach. The analysis showed the presence of ten compounds, out of which 11-hydroxycephalotaxin exhibited potential synergy as an inhibitor of 3CLpro, RdRp, and hACE2. The ADME analysis offered a corroborating profile, suggesting that this compound holds promise as a viable drug candidate within the biological system. M. longipeda has potent antiviral activity against covid-19, by 11-hydroxycephalotaxine. Further studies are needed to prove its activity as a covid-19 antiviral agent, such as in vitro and in vivo approaches. © 2023, BIOFLUX SRL. All rights reserved.
Institut Teknologi & Sains Nahdlatul Ulama Pasuruan, Warung Dowo, Pohjentrek, Pasuruan Regency, East Java, 67171, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, University Brawijaya, Veteran Street, Biology Building, Malang, 65145, Indonesia; Biology Study Program, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Jln. Ketintang, Gayungan, Surabaya, 60231, Indonesia; Chemistry Study Program, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Jln. Ketintang, Gayungan, Surabaya, 60231, Indonesia
