Sari E. Cahyaningrum, Fitriari I. Muhaimin, Amalia P. Purnamasari, Fasih B. Ilhami, Misni B. Misran
Diabetic wounds require a complex healing approach due to the wound’s environment, which is susceptible to infection and the inhibit regeneration process. This study aims to formulate and characterize a modified chitosan hydrogel incorporating the combination of natural extracts, namely Aloe Vera, Binahong (Anredera cordifolia) leaves, black cumin (Nigella sativa), and Snail Mucus as a candidate for a multifunctional diabetic wound dressing. The hydrogel was prepared by modifying chitosan with a cross-linker and combining the four extracts, which have antibacterial, anti-inflammatory, and cell-proliferation-stimulating properties. The characterization of the hydrogel included analysis of physicochemical properties, functional groups, swelling ratio, degradation time, and antibacterial testing. Our data shows that the formulated hydrogel had a porous structure, high absorption capacity, and strong antibacterial activity against pathogenic bacteria. This study has shown that chitosan hydrogel enriched with a combination of Aloe vera, binahong, nanosilver, black cumin, and snail mucus has great potential as an ideal diabetic wound dressing agent. This formulation creates a moist environment, control infection, and accelerate the tissue regeneration process. © 2026 Cahyaningrum et al.
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Jl. Ketintang, Gayungan, East Java, Surabaya, 60231, Indonesia; Department of Biology, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Jl. Ketintang, Gayungan, East Java, Surabaya, 60231, Indonesia; Department of Sains Education, Faculty of Science and Mathematics, Universitas Negeri Surabaya, Surabaya, 60231, Indonesia; Department of Chemistry, Faculty of Science, Universiti Malaya, Kuala Lumpur, Malaysia
