Alvisyah Nazarend, Nuniek Herdyastuti, Prima R. Wikandari
The study was carried out to evaluate the role of fermented single bulb garlic (FSBG) with lactobacillus plantarum B1765 toward insulin–glucagon axis in Type 2 diabetes mellitus (T2DM). The research assessed the influences of FSBG administration at doses of 100, 200, and 300 mg/kg, (while metformin (9 mg/kg) served as the reference treatment) on the insulin regulation and secretion of glucagon in experimental rats induced with a high-fat diet (HFD) and 20 mg/kg streptozotocin (STZ). The outcomes indicate that FSBG effectively reduced insulin–glucagon axis secretion with the optimal effect observed at a dose of 300 mg/kg. While the reduction in insulin levels achieved by FSBG was not significantly different from that of metformin, FSBG demonstrated a superior effect in lowering glucagon levels. Hence, FSBG can serve as a potential alternative antidiabetic agent, offering beneficial bioactive compounds suitable for long-term consumption compared to conventional drugs such as metformin, which may cause adverse side effects. © 2026 Nazarend et al.
Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Surabaya, Surabaya, Indonesia
