Cytotoxic Activity of Xanthones from the Stem Bark of Cratoxylum sumatranum

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Shola Mardhiyyah, Mufidatuz Zakiyah, Erika D. Renata, Tjitjik S. Tjahjandarie, Unang Supratman, Rurini Retnowati, Ratih D. Saputri, Mulyadi Tanjung

2023 Tropical Journal of Natural Product Research Vol. 7 Issue 9 Article Cited by 5 Quartile

Abstract

Two xanthones, gerontoxanthone I and macluraxanthone, were isolated from the stem bark of Cratoxylum sumatranum. Their structures were determined based on UV, HRESI-MS, 1D, and 2D NMR spectral data. Compounds 1 and 2 showed high activity against T47D cells with an IC50 of 1.10 and 1.60 μg/mL. © 2023 Mardhiyyah et al.

Affiliations

Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jatinangor, 45363, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Brawijaya, Malang, 65145, Indonesia; Organic Chemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya, 60231, Indonesia