Prima R. Wikandari, Nuniek Herdyastuti, Tukiran, Shod A. Dzulkarnain
The health-promoting components of single-bulb garlic are often enhanced by fermenting microorganisms during fermentation. Therefore, this research aimed to assess the antidiabetic effect of fermented single-bulb garlic (FSBG) using Lactobacillus plantarum B1765 on type 2 diabetes mellitus (T2DM) rats. The variables evaluated were peripheral blood glucose, venous blood glucose, and pancreatic β-cells. T2DM was induced in the experimental rats using a combination of a high-fat diet (HFD) and a low dose of streptozotocin (STZ). Antidiabetic effects of FSBG were compared with metformin, and the results showed that FSBG reduced peripheral blood glucose levels after 2–8 hours. In the longer term, 300 mg/kg of FSBG also significantly reduced venous blood glucose levels compared to metformin. The pancreatic β-cells were also significantly increased after 300 mg/kg FSBG oral doses. In conclusion, FSBG could be a potential source of antidiabetic constituents with good antidiabetic effects compared to conventional drugs such as metformin. © 2024 Wikandari et al.
Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Surabaya, Surabaya, 60231, Indonesia
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