Ratih D. Saputri, Tukiran, Suyatno, First A.wati, Shod A. Dzulkarnain, Mufidatuz Zakiyah, Tjitjik S. Tjahjandarie, Mulyadi Tanjung
The genus Calophyllum (Calophyllaceae) is a plant proven to produce various xanthones, chromanoic acids, and 4-phenyl coumarins. This study aims to determine the xanthine oxidase inhibitory activity of xanthones from Calophylum pseudomole P.F. Stevens. Two xanthones, ananixanthone (1) and caloxanthone L (2), were isolated from Calophyllum pseudomole stem barks. The structures of both xanthones were determined based on UV, HRESI-MS, 1D, and 2D NMR spectral data. Compounds 1-2 showed xanthine oxidase inhibitory activity with an IC50 of 15.05 and 17.7 μM, respectively, and were categorized as potent. © 2024 Saputri et al.
Organic Chemistry, Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya, 60231, Indonesia; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia
