Noto Susanto Gultom, Fasih Ilhami Bintang, Misganaw Alemu Zeleke, Aulia Sukma Hutama, Dong-Hau Kuo, Mati Horprathum, Camellia Panatarani, Ferry Faizal, Budi Adiperdana
Overuse of antibiotics has reduced effective medications, requiring research to combat drug-resistant bacteria and superbugs. This work explores the synthesis of a p-n junction ZnO/Ag2O composite for antibacterial photodynamic therapy. The as-prepared sample was thoroughly characterized using optical and structural analyses, scanning and transmission electron microscopy, and X-ray photoelectron spectroscopy. Our ZnO/Ag2O composite outperformed pristine ZnO in deactivating bacterial while also demonstrating high biocompatibility with normal cells. In silico molecular docking demonstrates that ZnO/Ag2O composite has a strong binding affinity for bacteria proteins, which exhibits great antibacterial activity against E. coli and S. aureus. © 2024 Elsevier B.V.
Department of Physics, Faculty of Mathematics and Natural Sciences, Universitas Padjadjaran, Jalan Raya Bandung-Sumedang 11 45363, Indonesia; Functional Nano Powder, University Center of Excellence, Universitas Padjadjaran, Jalan Raya Bandung-Sumedang KM 21, Sumedang, Jatinangor, 45363, Indonesia; Department of Natural Science, Faculty of Mathematics and Natural Science, Universitas Negeri Surabaya, Surabaya, 60231, Indonesia; Department of Chemical Sciences, University of Limerick, Limerick, V94 T9PX, Ireland; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Gadjah Mada, Sekip Utara, Yogyakarta, Bulaksumur, 55281, Indonesia; Department of Materials Science and Engineering, National Taiwan University of Science and Technology, No.43, Sec. 4, Keelung Road, Taipei, 10607, Taiwan; Graduate Institute of Energy and Sustainability Technology, National Taiwan University of Science and Technology, No.43, Sec. 4, Keelung Road, Taipei, 10607, Taiwan; Opto-Electrochemical Sensing Research Team, National Electronics and Computer Technology Center, Pathum Thani, 12120, Thailand
