Lidya Tumewu, Hilkatul Ilmi, Defi Kartika Sari, Adita Ayu Permanasari, Hanifah Khairun Nisa, Ratih Dewi Saputri, Tjitjik Srie Tjahjandarie, Mulyadi Tanjung, Che Puteh Osman, Nor Hadiani Ismail, Suciati, Aty Widyawaruyanti, Achmad Fuad Hafid
Three new dihydrochalcones: artoserichalcone A-C (1-3), were isolated from the leaves of Artocarpus sericicarpus. The structures of compounds were determined based on NMR spectrum (1H, 13C, and 2D) and HRESIMS spectroscopic analysis. Compounds (1) and (3) showed active antimalarial activity with IC50 values of 16.90 and 13.56 µM, respectively. Meanwhile, compound (2) with an IC50 value of 63.01 µM was categorised as a moderate antimalarial substance. The cytotoxicity against Huh7, HepG2, BHK-21, and Vero cells showed that compounds (1-3) with CC50 values > 20 µg/mL could be considered non-cytotoxic. Compounds (1-3) exhibited antimalarial activity against Plasmodium falciparum and non-toxic as an antimalarial agent. © 2024 Informa UK Limited, trading as Taylor & Francis Group.
Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia; Natural Product Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia; Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya, Indonesia; Natural Product Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia; Atta-ur-Rahman Institute for Natural Product Discovery, Universiti Teknologi MARA, Selangor, Bandar Puncak Alam, Malaysia; Faculty of Applied Sciences, Universiti Teknologi MARA, Selangor, Shah Alam, Malaysia; Department of Pharmaceutical Sciences, Faculty of Pharmacy, Universitas Airlangga, Surabaya, Indonesia
