Lilik Farkhiyah, Marshellia Ghinanda Dewistamara, Tukiran Tukiran
Most fungal human infections are caused by Candida species, especially Candida albicans. C. albicans is a highly adaptable microorganism that can cause resistance after prolonged exposure to antifungals. C. albicans is easily transmitted therefore the discovery of new antifungal agents is very urgent. Therefore, this study aims to find antifungal agents from natural materials, namely wild tantan leaves in silico and in vitro. In the in silico test with protein 2QZX, of the 10 dominant compounds from LC-MS results, 3 compounds were obtained that had the most potential as antifungals with binding affinity values lower than ketoconazole. On the other hand, in the in vitro test with the agar diffusion method using disc paper, the average inhibition zone value was 0.01283 m and was classified as strong. © 2025 Society of Pharmaceutical Sciences of Ankara (FABAD). All rights reserved.
Department of Chemistry, Faculty of Mathematics and Natural Science, Universitas Negeri Surabaya, Surabaya, Indonesia; Department of Biology, Faculty of Mathematics and Natural Science, Universitas Negeri Surabaya, Surabaya, Indonesia
