Ratih Dewi Saputri, First Ambar Wati, Amalia Putri Purnamasari, Hilkatul Ilmi, Tjitjik Srie Tjahjandarie, Shola Mardhiyyah, Mulyadi Tanjung
Three novel dihydrochalcones, flemilineatins C–E (1–3), and two known flavanones (4–5) were isolated from Flemingia lineata (L.) W.T. Aiton leaves. Dihydrochalcones 1–3 structures were established using NMR spectrum and high-resolution ESIMS data. Compounds 1–5 were assayed to Plasmodium falciparum lactate dehydrogenase (PfLDH) for their antiplasmodial activity. Compounds 2 and 5 exhibited high activity with an IC50 value of 0.74 and 0.79 µg/mL, respectively. © 2024 Informa UK Limited, trading as Taylor & Francis Group.
Department of Chemistry, Faculty of Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya, Indonesia; Center of Natural Products Medicine Research and Development, Institute of Tropical Disease, Universitas Airlangga, Surabaya, Indonesia; Natural Products Chemistry Research Group, Organic Chemistry Division, Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia
