Xanthones from the Roots of Garcinia rigida Miq. and Their Cytotoxic Activity against HeLa Cervical Cancer Lines

Audrey H. Zulfa; Salwa Assyifa; Ahmad R. Setiawan; Mulyadi Tanjung; Tjitjik S. Tjahjandrie; Ratih D. Saputri

doi:10.26538/tjnpr/v9i4.5

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Xanthones from the Roots of Garcinia rigida Miq. and Their Cytotoxic Activity against HeLa Cervical Cancer Lines

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Audrey H. Zulfa, Salwa Assyifa, Ahmad R. Setiawan, Mulyadi Tanjung, Tjitjik S. Tjahjandrie, Ratih D. Saputri

2025 Tropical Journal of Natural Product Research Vol. 9 Issue 4 Article Cited by 2 SDG 3

Abstract

Garcinia rigida Miq. (Clusiaceae), a plant endemic to Borneo is a traditional medicine in Kalimantan, Indonesia. Xanthones are a promising metabolomic substance of Garcinia for cancer therapy. This research aimed to evaluate the cytotoxicity against HeLa cells of xanthones from the roots of Garcinia rigida Miq. Two xanthones, mangostanin (1) and 8-isoprenyl-1,6,7-trihydroxy-6',6'-dimethyl-pyrano(2',3':3,2)xanthone (2), were isolated from the roots of G. rigida. Xanthones 1-2 molecular structures were established and focused using1H,13C, HMQC, and HMBC spectra. Xanthones 1-2 were assayed regarding their cytotoxicity against HeLa cells using the MTT method. Compound 2 exhibited moderate cytotoxicity with an IC50 of 21.89 µM. © 2025 the authors.

Affiliations

Department of Chemistry, Faculty Mathematics and Natural Sciences, Universitas Negeri Surabaya, Surabaya, 60231, Indonesia; Department of Chemistry, Faculty of Science and Technology, Universitas Airlangga, Surabaya, Indonesia

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