Syerlistya Putri Dahliyanti, Teguh Hari Sucipto, Ahmad Rudi Setiawan, Syananda Zahra Fadila, Andika Pramudya Wardana, Ratih Dewi Saputri, Hariyono
DENV infection has become an endemic disease in Indonesia and numerous attempts are currently being undertaken to prevent and treat DENV infection, such as finding vaccines and other medications. This research aims to understand the synthesized compound's characteristics, and antibacterial and anti-DENV activities, explicitly focusing on the Cu (II)-EDTA complex. Cu (II)-Ethylenediaminetetraacetic acid (EDTA) has been successfully synthesized using the solvothermal method and read tested for antibacterial and anti-DENV2 activities. Cu (II)-EDTA complex compounds are characterized by FTIR (Fourier Transform Infrared Spectroscopy), UV-Vis (Ultraviolet-Visible), SEM (Scanning Electron Microscopy), DSC (Differential Scanning Calorimetry), and PSA (Particle Size Analyzer). The Cu-(II)-EDTA particle size was 6.91 nm with a PDI value of 0.0808. The morphology of a crystal is a cube with a rough and irregular surface. The Cu (II)-EDTA complex demonstrated notable activity against gram-negative bacteria (Escherichia coli) and gram-positive bacteria (Staphylococcus aureus) with a zone of inhibition 8.83 ± 1.30 and 12.06 ± 1.26 mm at a concentration of 250 mg/mL, respectively. Furthermore, cytotoxicity against Vero cell and anti-DENV2 was observed with a CC50 of 415.44 μg/mL and IC50 of 270.98 μg/mL. The results of the characterization suggest that Cu (II)-EDTA could be used as an antibacterial against E. coli, S. aureus, and anti-DENV2 agent. © 2025 by SPC (Sami Publishing Company).
Department of Chemistry, Faculty of Mathematics of Natural Sciences, Universitas Negeri Surabaya, Surabaya, 60231, Indonesia; Dengue Study Group, Institute of Tropical Disease, Universitas Airlangga, Surabaya, 60115, Indonesia; Postgraduate School, Universitas Airlangga, Surabaya, 60286, Indonesia
